Research

Griffith Laboratory

Research Summary:

Dr. James W. Griffith is a clinical psychologist with a strong background in research, statistics, patient-reported outcomes, and behavioral interventions. At the University of Chicago, he is embedded in both the Department of Psychiatry and Behavioral Neuroscience, as well as the Department of Obstetrics and Gynecology, Division of Urogynecology and Reconstructive Pelvic Surgery. This dual appointment allows his lab to focus on the intersection of mental health with a broad range of medical concerns. In addition to his research experience, Dr. Griffith is a licensed clinical psychologist who treats patients with severe depression and anxiety using evidence-based approaches such as cognitive behavior therapy (CBT). The Griffith Lab leverages expertise in clinical assessment, research methodology, and psychometrics to develop clinical measurement tools and behavioral interventions with an emphasis on patient-reported outcomes. 

 

Dr. Francesca Farina is a Research Assistant Professor in the Griffith Lab. A trained neuroscientist, Dr. Farina leads a dedicated line of research on women’s brain health with a particular focus on modifiable factors that influence risk for Alzheimer’s disease and related dementias. Her work emphasizes the importance of early detection, with a goal of identifying both risk and resilience factors that emerge during key life transitions, such as menopause.

Dr. Farina co-leads the PERI-MIND intervention study, designed for perimenopausal and early postmenopausal individuals who may be at increased risk for cognitive decline. Through collaborations with multidisciplinary teams, Dr. Farina aims to close the gap in dementia research that has historically overlooked sex-specific mechanisms.

Beyond the lab, Dr. Farina works actively with patient advocacy groups and community-based organizations to promote brain health literacy and reduce stigma surrounding cognitive decline and neurodegenerative diseases. She is committed to advancing equitable, informed, and proactive approaches to brain health for all.

James William Griffith, PhD

Professor of Obstetrics and Gynecology
Professor of Psychiatry and Behavioral Neuroscience

Francesca Farina

Francesca Farina, PhD

Research Assistant Professor, Griffith Lab

Main Projects

 

Dr. Farina's Project Recruitment

2023-2028

Brain-based and clinical phenotyping of pain pharmacotherapy in knee osteoarthritis: NIAMS 1R01AR081854-01A1

 

  • NIH/NCI Principal Investigator: V. Apkarian, J. W. Griffith, T. Schnitzer
  • Specific Aim: To identify specific biomarkers in individual people with osteoarthritis (OA) pain that will allow definition of responder phenotypes distinct for different therapeutic interventions

2022 – 2027

Enhanced Clinical Decisions for Management of Benign Prostatic Hyperplasia Using Patient-Reported Outcomes: NIDDK 1R01DK130963-01A1

  • NIH/NCI Principal Investigator: J. W. Griffith, A. Glaser, & A. Smith
  • Specific Aim: To use LURN questionnaires and other PROs to enhance clinical decision-making in men with BPH

2022 – 2027

RO Interpretation at the Individual Level for Patients with Cancer using Conversational Agents and Data Visualization: NCI 1R01CA271145-01

  • NIH/NCI Principal Investigator: J. W. Griffith, M. Paasche-Orlow
  • Specific Aim: TO develop and evaluate an Embodied Conversational Agent – Patient-Reported Outcome (ECA-PRO) smartphone system that engages patients with interactive communication and empathy, while delivering standard PROs in a way that minimizes missing data and enables user-friendly visual sharing of results

2021 – 2025

Reducing Disparities in Urinary Control Symptoms for Minority Women: NIDDK 1R01DK129849-0

  • NIH/NCI Principal Investigator: J. W. Griffith, K. Kenton, & M. Simon
  • Specific Aim: To evaluate the feasibility and efficacy of a culturally-specific, home-based, community health-worker (CHW) supported, conservative intervention for UI/LUTS
2020-2025

Northwestern University PLUS Clinical Site: NIDDK 5U01DK126045-02

  • NIH/NCI Principal Investigator: J. W. Griffith, K. Kenton, & M. Simon
  • Specific Aim: To assess the influence of biological, psychosocial (mind/behavior), interpersonal, institutional, environmental, and societal factors on bladder health among diverse women using qualitative and quantitative approaches within the PLUS framework
2024-2025

LURN II: Enhanced Characterization of Patients with LUTS Using Biopsychosocial Approaches: NIDDK 7U01DK097779-12 

  • NIH/NCI Principal Investigator: J.W. Griffith, B. Helfand & K. Kenton
  • Specific Aim: To refine our ability to subtype patients by developing a biomarker panel that can be used in a clinical setting to phenotype patients, as well as through other patient assessment data gleaned from questionnaires, mobile apps, and laboratory-based testing
2021 - 2025

Does fear of dementia influence modifiable risk factors for dementia?

  • NIH/NIC Principal Investigator: F. Farina
  • Specific Aim: To determine if dementia-related fear and avoidance behaviors influence modifiable risk factors for dementia
  • Sponsor: Alzheimer's Association Research Fellowship (AARF)
2024-2025

Development of a Personalized, Psychosocial Intervention for Menopausal Individuals with Elevated Dementia Risk (PERI-MIND)

  • NIH/NCI Principal Investigator: F. Farina
  • Specific Aim: To develop, and pilot test a brief personalized, psychosocial intervention for middle-aged perimenopausal individuals with elevated dementia risk
  • Sponsor: The Menopause Society